Inflammatory Bowel Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Combined therapy with 5-ASA + Adalimumab led to the strongest changes in marker modulation: IL-4, IL-5, IL-15, and PDGF-BB, were upregulated (P < .05).Elevated serum levels of G-CSF, IL-1Ra, and PDGF-BB were associated with IBD endoscopic activity, and of IP-10 with extraintestinal manifestations of IBD.
|
31567972 |
2019 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interleukin 1 is a key driver of inflammatory bowel disease-demonstration in a murine IL-1Ra knockout model.
|
31191826 |
2019 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
IL-1RA Mspa-I11100 CT was associated with earlier age of onset in IBD, while TT genotype was associated with higher age of onset in IBD.
|
25466956 |
2015 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The IL-1RN*2 mutation may play a role in Northern European people with inflammatory bowel disease.
|
19643686 |
2010 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The aim of this study was to examine the allelic polymorphisms that can determine the immune response levels in tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1B), interleukin-1 receptor antagonist ( IL-1RN) and interleukin-10 (IL-10) genes and to investigate their roles in the inflammatory pathway in IBD.
|
16638698 |
2006 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In the present study the aim was to assess the allele frequencies and carriage rates of different alleles of 86 bp (base pair) variable number tandem repeat (VNTR) in intron 2 of the IL-1Ra gene in patients with inflammatory bowel disease (IBD) and healthy controls from northern India.
|
16109659 |
2005 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These results support the hypothesis that the IL-1ra VNTR-polymorphism could be among the genetic factors that are of importance in IBD susceptibility.
|
12424621 |
2002 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The genetic relationship between IBD and the interleukin-1 receptor antagonist and interleukin-1beta genes (IL-1RN, and IL-1B, respectively) has been extensively studied.
|
11686217 |
2001 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To determine whether the decreased bone mass in IBD is related to gene polymorphisms coding for IL-1beta and IL-1ra, and thus identify patients with an increased risk.
|
11600466 |
2001 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The population differences in allelic frequencies of the IL-1 gene cluster and IL-1Ra concentrations suggest that genetic and environmental factors play an important role in susceptibility to IBD.
|
11220627 |
2001 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The allele status of the interleukin 1 receptor antagonist (IL-1ra), IL-6, heat shock protein 70-2 (hsp 70-2), and heat shock protein 70-hom (hsp hom) genes was typed and correlated with clinical course of IBD and extent of bone loss.
|
11040178 |
2000 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This study aimed to determine the association between intron 2 IL-1ra polymorphism and IBD by performing a multiethnic case-control study and to assess its functional significance.
|
10500062 |
1999 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Significant differences in the interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in a Hungarian population with inflammatory bowel disease.
|
10192196 |
1999 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
To study allelic frequencies of novel polymorphisms in the genes for IL-1 beta and IL-1ra in patients with IBD and to assess the relation between ex vivo cytokine production and allelic variants of the IL-1 beta and IL-1ra genes.
|
9771403 |
1998 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Thus, we could not confirm the results of a previous study reporting an association between the IL-1ra and IL-1 beta gene polymorphisms in patients with inflammatory bowel disease.
|
9568467 |
1998 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-1ra:(IL-1 alpha+beta) ratios were significantly decreased in inflamed mucosa of patients with CD (182 (45); p < 0.0001), UC (425 (136); p = 0.0018) and without IBD (221 (76); p < 0.0001), and in non-inflamed mucosa in CD (369 (149); p < 0.0001) compared with normal controls (1307 (245); p < 0.0001).
|
9414973 |
1997 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Significance of interleukin-1beta and interleukin-1 receptor antagonist genetic polymorphism in inflammatory bowel diseases.
|
9219791 |
1997 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To study allelic frequencies of polymorphisms of the interleukin-1 receptor antagonist (IL-1RA) gene and the tumour necrosis factor alpha gene in patients with inflammatory bowel disease.
|
9014770 |
1996 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This article will review current progress in understanding the role of Il-1 and Il-1ra in IBD, as well as discuss recently described polymorphisms in the Il-1 gene cluster and their association with UC and CD.
|
8899101 |
1996 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Allelic polymorphism in IL-1 beta and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease.
|
7586694 |
1995 |